The Amazing Spider-Man #310 (1988)
Writer: David Michelinie
Artist: Todd McFarlane
Peter starts college again. He notices his spider sense tingle in the lab he’s assigned to. He comes back at night as Spider-Man and finds the Tinkerer in a back room making a weapon enhancer for Killer Shrike, who shows up right then. Killer Shrike attempts a double cross, but Tinkerer added a safeguard for such an event and Shrike is down for the count. Tinkerer escapes but Spidey gets Shrike to jail.