The Amazing Spider-Man #221 (1981)
“Blues For Lonesome Pinky!”
Writer: Denny O’Neil
Artist: Alan Kupperberg
A villain named Ramrod with a steel plate on the back of his head has poisoned the drinks at a bar as an act of vengeance against the owner. Spider-Man finds the antidote and comes back, fights off Ramrod, and gives the antidote to everybody.