The Spectacular Spider-Man #181 (1991)
“The Child Within, Part Four: Guilt”
Writer: J.M. DeMatteis
Artist: Sal Buscema
Green Goblin hits Peter with hallucinogenic gas which causes him to think about all the guilt he has over everybody that has died because of Spider-Man. It leads him to realize that the root of it all is about the death of his parents and he goes crazy and tears up the place and swings out (without his mask on) and crashes into Dr. Kafka’s office. Vermin shows up back at his old home and tells his dad he’s going to kill him.