The Amazing Spider-Man #313 (1989)
Writer: David Michelinie
Artist: Todd McFarlane
Peter and Mary Jane fight a giant shark in tunnel to Queens on their way to see Aunt May. When they get there, Mary Jane’s cousin tells them May went to find Peter. Peter runs off to find her. May comes back then, saying that transportation is stopped going into the city. Curt Connors turns into The Lizard again. His family comes to see him at ESU but they’re attacked by demons. Lizard fights them off so he can have the Connors family for himself. After Spider-Man pops a demonized blimp of himself, he goes to ESU and fights the Lizard, eventually managing to change him back to Connors. Connors tells his wife and son to go far away and never tell him where. Jonathan Caesar (previous kidnapper of Mary Jane) hatches some sinister revenge plans for Mary Jane from the prison yard.